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Antibody Product Overview
| ELK.No | ES2635 |
| Product name | IP3KA rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | ITPKA; Inositol-trisphosphate 3-kinase A; Inositol 1; 4,5-trisphosphate 3-kinase A; IP3 3-kinase A; IP3K A; InsP 3-kinase A |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 3706 |
| Human Swiss-Prot | P23677 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IP3KA |
| Fields | >>Inositol phosphate metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Phosphatidylinositol signaling system |
| Gene name | ITPKA |
| Protein name | Inositol-trisphosphate 3-kinase A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 228550 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8R071 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81677 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P17105 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IP3KA. AA range:396-445 |
| Specificity | IP3KA Polyclonal Antibody detects endogenous levels of IP3KA protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 52kD |
| Background | Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011], |
| Function | catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin.,similarity:Belongs to the inositol phosphokinase (IPK) family., |
| Subcellular location | Cytoplasm, cytoskeleton . |
| Expression | Expressed in brain. |
Additional Images
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Western Blot analysis of various cells using IP3KA Polyclonal Antibody
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Western blot analysis of lysates from HUVEC cells, using IP3KA Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES2635-50
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