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Antibody Product Overview
| ELK.No | ES2658 |
| Product name | JIK rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | TAOK3; DPK; JIK; KDS; MAP3K18; Serine/threonine-protein kinase TAO3; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhi |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 51347 |
| Human Swiss-Prot | Q9H2K8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | JIK |
| Fields | >>MAPK signaling pathway |
| Gene name | TAOK3 |
| Protein name | Serine/threonine-protein kinase TAO3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 330177 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BYC6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 304530 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q53UA7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TAOK3. AA range:531-580 |
| Specificity | JIK Polyclonal Antibody detects endogenous levels of JIK protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 110kD |
| Background | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Also localized to the peripheral cell membrane.,subunit:Self-associates.,tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver., |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Also localized to the peripheral cell membrane.,subunit:Self-associates.,tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver., |
| Subcellular location | Cytoplasm . Cell membrane ; Peripheral membrane protein . Also localized to the peripheral cell membrane. |
| Expression | Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |
Additional Images
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Western Blot analysis of various cells using JIK Polyclonal Antibody
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Western Blot analysis of Jurkat cells using JIK Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES2658-50
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