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Antibody Product Overview
| ELK.No | ES2721 |
| Product name | LOK rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA;IHC |
| Other name | STK10; LOK; Serine/threonine-protein kinase 10; Lymphocyte-oriented kinase |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6793 |
| Human Swiss-Prot | O94804 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LOK |
| Fields | >>Progesterone-mediated oocyte maturation |
| Gene name | STK10 |
| Protein name | Serine/threonine-protein kinase 10 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O55098 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STK10. AA range:491-540 |
| Specificity | LOK Polyclonal Antibody detects endogenous levels of LOK protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 120kD |
| Background | This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed predominantly in lymphoid organs., |
| Subcellular location | Cell membrane ; Peripheral membrane protein . |
| Expression | Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. |
Additional Images
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Western Blot analysis of various cells using LOK Polyclonal Antibody
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Western Blot analysis of HuvEc cells using LOK Polyclonal Antibody
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Western blot analysis of the lysates from HT-29 cells using STK10 antibody.
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES2721-50
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