Français
English
Antibody Product Overview
| ELK.No | ES2960 |
| Product name | NGFR p75 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4804 |
| Human Swiss-Prot | P08138 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NGFR p75 |
| Fields | >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Cytokine-cytokine receptor interaction;>>PI3K-Akt signaling pathway;>>Apoptosis - multiple species;>>Neurotrophin signaling pathway;>>Transcriptional misregulation in cancer |
| Gene name | NGFR |
| Protein name | Tumor necrosis factor receptor superfamily member 16 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9Z0W1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24596 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P07174 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNR16. AA range:121-170 |
| Specificity | NGFR p75 Polyclonal Antibody detects endogenous levels of NGFR p75 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008], |
| Function | domain:Death domain is responsible for interaction with RANBP9.,domain:The extracellular domain is responsible for interaction with NTRK1.,function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDI |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine . |
| Expression | Brain, |
Additional Images
No image
Western Blot analysis of various cells using NGFR p75 Polyclonal Antibody
No image
Western Blot analysis of HepG2 cells using NGFR p75 Polyclonal Antibody
No image
Immunofluorescence analysis of A549 cells, using TNR16 Antibody. The picture on the right is blocked with the synthesized peptide.
No image
Western blot analysis of lysates from HepG2 cells, using TNR16 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES2960-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package