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Antibody Product Overview
| ELK.No | ES3088 |
| Product name | OTUD2 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | YOD1; DUBA8; HIN7; OTUD2; Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 55432 |
| Human Swiss-Prot | Q5VVQ6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | OTUD2 |
| Fields | >>Protein processing in endoplasmic reticulum |
| Gene name | YOD1 |
| Protein name | Ubiquitin thioesterase OTU1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8CB27 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human YOD1. AA range:116-165 |
| Specificity | OTUD2 Polyclonal Antibody detects endogenous levels of OTUD2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 35kD |
| Background | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013], |
| Function | function:Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.,sequence caution:Wrong choice of frame.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 OTU domain., |
| Subcellular location | Cytoplasm . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. . |
| Expression | Fetal liver,Spinal cord,Testis, |
Additional Images
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Western Blot analysis of various cells using OTUD2 Polyclonal Antibody
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Western blot analysis of lysates from COLO cells, using YOD1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HT-29 cells using YOD1 antibody.
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: AO-06-ES3088-100
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