Français
English
Antibody Product Overview
| ELK.No | ES3247 |
| Product name | PP2A-Aβ rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | PPP2R1B; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5519 |
| Human Swiss-Prot | P30154 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PP2A-Aβ |
| Fields | >>mRNA surveillance pathway;>>Sphingolipid signaling pathway;>>Oocyte meiosis;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Tight junction;>>Dopaminergic synapse;>>Long-term depression;>>Chagas disease;>>Hepatitis C;>>Human papillomavirus infection |
| Gene name | PPP2R1B |
| Protein name | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 73699 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q7TNP2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 315648 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q4QQT4 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPP2R1B. AA range:552-601 |
| Specificity | PP2A-Aβ Polyclonal Antibody detects endogenous levels of PP2A-Aβ protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 66kD |
| Background | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010], |
| Function | disease:Defects in PPP2R1B might be a cause of some lung and colorectal cancers.,domain:Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.,function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the phosphatase 2A regulatory subunit A family.,similarity:Contains 15 HEAT repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate wi |
| Subcellular location | membrane raft,extracellular exosome, |
| Expression | Testis, |
Additional Images
No image
Western Blot analysis of various cells using PP2A-Aβ Polyclonal Antibody
No image
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PPP2R1B Antibody. The picture on the right is blocked with the synthesized peptide.
No image
Western blot analysis of lysates from HeLa and Jurkat cells, using PPP2R1B Antibody. The lane on the right is blocked with the synthesized peptide.
No image
Western blot analysis of the lysates from Jurkat cells using PPP2R1B antibody.
: AO-06-ES3247-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package