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Antibody Product Overview
| ELK.No | ES3381 |
| Product name | RIN3 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA;IHC |
| Other name | RIN3; Ras and Rab interactor 3; Ras interaction/interference protein 3 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 79890 |
| Human Swiss-Prot | Q8TB24 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RIN3 |
| Fields | |
| Gene name | RIN3 |
| Protein name | Ras and Rab interactor 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P59729 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RIN3. AA range:391-440 |
| Specificity | RIN3 Polyclonal Antibody detects endogenous levels of RIN3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 107kD |
| Background | Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
| Function | caution:The region from Asp-168 to Pro-327 is deduced from the genomic sequence by similarity to the mouse sequence.,function:Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP.,similarity:Belongs to the RIN (Ras interaction/interference) family.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 VPS9 domain.,subcellular location:Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.,subunit:Interacts with RAB5B and BIN1.,tissue specificity:Widely expressed., |
| Subcellular location | Cytoplasm . Cytoplasmic vesicle . Early endosome . Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. . |
| Expression | Widely expressed. |
Additional Images
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Western Blot analysis of various cells using RIN3 Polyclonal Antibody
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Western blot analysis of lysates from HUVEC and K562 cells, using RIN3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES3381-50
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