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Antibody Product Overview
| ELK.No | ES3405 |
| Product name | Sam 68 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | KHDRBS1; SAM68; KH domain-containing; RNA-binding, signal transduction-associated protein 1; GAP-associated tyrosine phosphoprotein p62; Src-associated in mitosis 68 kDa protein; Sam68; p21 Ras GTPase-activating protein-associated p62; p68 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10657 |
| Human Swiss-Prot | Q07666 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Sam 68 |
| Fields | |
| Gene name | KHDRBS1 |
| Protein name | KH domain-containing RNA-binding signal transduction-associated protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20218 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60749 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 117268 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q91V33 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Sam 68. AA range:96-145 |
| Specificity | Sam 68 Polyclonal Antibody detects endogenous levels of Sam 68 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 68kD |
| Background | This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012], |
| Function | developmental stage:Isoform 3 is only expressed in growth-arrested cells.,domain:The KH domain is required for binding to RNA.,domain:The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methlylation on these motifs can modulate protein-protein interactions.,function:Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.,function:Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as |
| Subcellular location | Nucleus . Cytoplasm . Membrane . Predominantly located in the nucleus but also located partially in the cytoplasm. . |
| Expression | Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. |
Additional Images
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Western Blot analysis of various cells using Sam 68 Polyclonal Antibody
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Western blot analysis of lysate from HUVEC cells, using Sam 68 antibody.
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: AO-06-ES3405-50
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