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Antibody Product Overview
| ELK.No | ES3454 |
| Product name | SLK rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | SLK; KIAA0204; STK2; STE20-like serine/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9748 |
| Human Swiss-Prot | Q9H2G2 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SLK |
| Fields | >>Oocyte meiosis |
| Gene name | SLK |
| Protein name | STE20-like serine/threonine-protein kinase |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20874 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O54988 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 54308 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O08815 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLK. AA range:1151-1200 |
| Specificity | SLK Polyclonal Antibody detects endogenous levels of SLK protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 150kD |
| Background | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Mediates apoptosis and actin stress fiber dissolution.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Proteolytically cleaved by caspase-3.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 422.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 611.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 614.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UVR domain.,tissue specificity:Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle., |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Mediates apoptosis and actin stress fiber dissolution.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Proteolytically cleaved by caspase-3.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 422.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 611.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 614.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UVR domain.,tissue specificity:Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle., |
| Subcellular location | Cytoplasm . |
| Expression | Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. |
Additional Images
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Western Blot analysis of various cells using SLK Polyclonal Antibody diluted at 1:1000
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Immunofluorescence analysis of HepG2 cells, using SLK Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using SLK Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from COLO205 cells, using SLK Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES3454-50
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