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Antibody Product Overview
| ELK.No | ES3475 |
| Product name | SNX1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | SNX1; Sorting nexin-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6642 |
| Human Swiss-Prot | Q13596 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SNX1 |
| Fields | >>Endocytosis |
| Gene name | SNX1 |
| Protein name | Sorting nexin-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56440 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9WV80 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 84471 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q99N27 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from the Internal region of human SNX1. |
| Specificity | SNX1 Polyclonal Antibody detects endogenous levels of SNX1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008], |
| Function | function:May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with PtdIns(3,4,5)P3 and, with weaker affinity, with PtdIns(3,5)P2.,similarity:Belongs to the sorting nexin family.,similarity:Contains 1 PX (phox homology) domain.,subunit:Self-assembles into a complex of approximately 300 kDa (By similarity). Interacts with HGS (By similarity). Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2., |
| Subcellular location | Endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium . Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stx |
| Expression | Brain,Coronary artery,Liver,Muscle,Testis, |
Additional Images
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Western Blot analysis of various cells using SNX1 Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES3475-50
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