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Antibody Product Overview
| ELK.No | ES3502 |
| Product name | SSBP1 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Cow |
| Applications | WB;IHC;IF;ELISA |
| Other name | SSBP1; SSBP; Single-stranded DNA-binding protein; mitochondrial; Mt-SSB; MtSSB; PWP1-interacting protein 17 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6742 |
| Human Swiss-Prot | Q04837 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SSBP1 |
| Fields | >>DNA replication;>>Mismatch repair;>>Homologous recombination |
| Gene name | SSBP1 |
| Protein name | Single-stranded DNA-binding protein mitochondrial |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 381760 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CYR0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 54304 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P28042 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MtSSB. AA range:99-148 |
| Specificity | SSBP1 Polyclonal Antibody detects endogenous levels of SSBP1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 17kD |
| Background | SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010], |
| Function | function:This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 SSB domain.,subunit:Homotetramer., |
| Subcellular location | Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid . |
| Expression | Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level). |
Additional Images
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Western Blot analysis of various cells using SSBP1 Polyclonal Antibody
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Immunofluorescence analysis of A549 cells, using MtSSB Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human pancreas tissue, using MtSSB Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from HUVEC and HeLa cells, using MtSSB Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES3502-50
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