Français
English
Antibody Product Overview
| ELK.No | ES3541 |
| Product name | Synuclein-β rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | SNCB; Beta-synuclein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6620 |
| Human Swiss-Prot | Q16143 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Synuclein-β |
| Fields | |
| Gene name | SNCB |
| Protein name | Beta-synuclein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 104069 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91ZZ3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 113893 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q63754 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Synuclein beta. AA range:85-134 |
| Specificity | Synuclein-β Polyclonal Antibody detects endogenous levels of Synuclein-β protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 14kD |
| Background | This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015], |
| Function | disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.,function:Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.,PTM:Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.,similarity:Belongs |
| Subcellular location | Cytoplasm. |
| Expression | Expressed predominantly in brain; concentrated in presynaptic nerve terminals. |
Additional Images
No image
Western Blot analysis of various cells using Synuclein-β Polyclonal Antibody
No image
Immunofluorescence analysis of A549 cells, using Synuclein beta Antibody. The picture on the right is blocked with the synthesized peptide.
No image
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Synuclein beta Antibody. The picture on the right is blocked with the synthesized peptide.
No image
Western blot analysis of lysates from HeLa cells, using Synuclein beta Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES3541-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package