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Antibody Product Overview
| ELK.No | ES3582 |
| Product name | TESK2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | TESK2; Dual specificity testis-specific protein kinase 2; Testicular protein kinase 2 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10420 |
| Human Swiss-Prot | Q96S53 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TESK2 |
| Fields | |
| Gene name | TESK2 |
| Protein name | Dual specificity testis-specific protein kinase 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 230661 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VCT9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 170908 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q924U5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TESK2. AA range:201-250 |
| Specificity | TESK2 Polyclonal Antibody detects endogenous levels of TESK2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | testis-specific kinase 2(TESK2) Homo sapiens This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
| Function | alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,cofactor:Manganese.,enzyme regulation:Activated by autophosphorylation on Ser-219.,function:Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,tissue specificity:Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells., |
| Subcellular location | Nucleus . |
| Expression | Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells. |
Additional Images
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Western Blot analysis of various cells using TESK2 Polyclonal Antibody
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Western blot analysis of the lysates from K562 cells using TESK2 antibody.
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: AO-06-ES3582-50
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