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Antibody Product Overview
| ELK.No | ES3755 |
| Product name | ALDH3A1 rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;ELISA |
| Other name | ALDH3A1; ALDH3; Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 218 |
| Human Swiss-Prot | P30838 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ALDH3A1 |
| Fields | >>Glycolysis / Gluconeogenesis;>>Histidine metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>beta-Alanine metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Metabolic pathways |
| Gene name | ALDH3A1 |
| Protein name | Aldehyde dehydrogenase dimeric NADP-preferring |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P47739 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25375 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P11883 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ALDH3A1. AA range:236-285 |
| Specificity | ALDH3A1 Polyclonal Antibody detects endogenous levels of ALDH3A1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008], |
| Function | catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homodimer.,tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney., |
| Subcellular location | Cytoplasm . |
| Expression | High levels in stomach, esophagus and lung; low level in the liver and kidney. |
Additional Images
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Western Blot analysis of extracts from A549, K562 cells, using ALDH3A1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western blot analysis of lysates from A549 cells, using ALDH3A1 antibody.
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: AO-06-ES3755-100
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