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Antibody Product Overview
| ELK.No | ES3757 |
| Product name | CHD1L rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | CHD1L; ALC1; Chromodomain-helicase-DNA-binding protein 1-like; Amplified in liver cancer protein 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9557 |
| Human Swiss-Prot | Q86WJ1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CHD1L |
| Fields | |
| Gene name | CHD1L |
| Protein name | Chromodomain-helicase-DNA-binding protein 1-like |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68058 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CXF7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CHD1L. AA range:545-594 |
| Specificity | CHD1L Polyclonal Antibody detects endogenous levels of CHD1L protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 101kD |
| Background | chromodomain helicase DNA binding protein 1 like(CHD1L) Homo sapiens This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012], |
| Function | function:Putative DNA helicase, which may play a role in chromatin-remodeling. In vitro, promotes cell proliferation and inhibits apoptois.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 Macro domain.,tissue specificity:Frequently overexpresssed in hepatomacellular carcinomas., |
| Subcellular location | Nucleus . Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1. . |
| Expression | Frequently overexpressed in hepatomacellular carcinomas. |
Additional Images
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Western Blot analysis of extracts from NIH-3T3, Jurkat, A549 cells, using CHD1L Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of lysates from HepG2 cells, using CHD1L antibody.
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: AO-06-ES3757-50
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