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Antibody Product Overview
| ELK.No | ES3932 |
| Product name | ADM rabbit pAb |
| Reactivity | Human;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | ADM; AM; ADM |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 133 |
| Human Swiss-Prot | P35318 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ADM |
| Fields | >>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction |
| Gene name | ADM |
| Protein name | ADM |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P97297 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25026 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P43145 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ADM. AA range:101-150 |
| Specificity | ADM Polyclonal Antibody detects endogenous levels of ADM protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014], |
| Function | function:AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.,similarity:Belongs to the adrenomedullin family.,tissue specificity:Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues., |
| Subcellular location | Secreted. |
| Expression | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. |
Additional Images
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Western Blot analysis of mouse kidney, mouse lung, mouse heart cells using ADM Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded rat-kidney, antibody was diluted at 1:100
: AO-06-ES3932-50
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