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Antibody Product Overview
| ELK.No | ES3993 |
| Product name | IL-1RI rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC;IF;ELISA |
| Other name | IL1R1; IL1R; IL1RA; IL1RT1; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD121a |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3554 |
| Human Swiss-Prot | P14778 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IL-1RI |
| Fields | >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>Th17 cell differentiation;>>Inflammatory mediator regulation of TRP channels;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Amoebiasis;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Fluid shear stress and atherosclerosis |
| Gene name | IL1R1 |
| Protein name | Interleukin-1 receptor type 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P13504 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human IL1R1. AA range:31-80 |
| Specificity | IL-1RI Polyclonal Antibody detects endogenous levels of IL-1RI protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013], |
| Function | function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP., |
| Subcellular location | Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted . |
| Expression | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. |
Additional Images
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Western Blot analysis of MCF7 cells using IL-1RI Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
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: AO-06-ES3993-100
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