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Antibody Product Overview
| ELK.No | ES4050 |
| Product name | NUMB rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB; IF;ELISA |
| Other name | NUMB; Protein numb homolog; h-Numb; Protein S171 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8650 |
| Human Swiss-Prot | P49757 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NUMB |
| Fields | >>Notch signaling pathway |
| Gene name | NUMB |
| Protein name | Protein numb homolog |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18222 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9QZS3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q2LC84 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from the Internal region of human NUMB. |
| Specificity | NUMB Polyclonal Antibody detects endogenous levels of NUMB protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 70kD |
| Background | The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
| Function | function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis., |
| Subcellular location | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. . |
| Expression | B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live |
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: AO-06-ES4050-50
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