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Antibody Product Overview
| ELK.No | ES4174 |
| Product name | Eotaxin rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CCL11; SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6356 |
| Human Swiss-Prot | P51671 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Eotaxin |
| Fields | >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>IL-17 signaling pathway;>>Asthma |
| Gene name | CCL11 |
| Protein name | Eotaxin |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20292 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P48298 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29397 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P97545 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CCL11. AA range:41-90 |
| Specificity | Eotaxin Polyclonal Antibody detects endogenous levels of Eotaxin protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 11kD |
| Background | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014], |
| Function | function:In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.,induction:By TNF-alpha, interleukin-1 alpha and interferon gamma.,online information:CCL11 entry,PTM:O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.,similarity:Belongs to the intercrine beta (chemokine CC) family., |
| Subcellular location | Secreted . |
| Expression | Blood,Foreskin,Lung,Placenta,Small intestine, |
Additional Images
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Western Blot analysis of HepG2, mouse thymus, mouse skeletal muscle cells using Eotaxin Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES4174-50
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