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Antibody Product Overview
| ELK.No | ES4176 |
| Product name | FOXP3 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Pig |
| Applications | WB;IHC;IF;ELISA |
| Other name | FOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 50943 |
| Human Swiss-Prot | Q9BZS1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FOXP3 |
| Fields | >>Th17 cell differentiation;>>Inflammatory bowel disease |
| Gene name | FOXP3 |
| Protein name | Forkhead box protein P3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20371 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99JB6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP3. AA range:381-430 |
| Specificity | FOXP3 Polyclonal Antibody detects endogenous levels of FOXP3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47kD |
| Background | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain., |
| Subcellular location | Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). . |
| Expression |
Additional Images
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Western Blot analysis of PC12 cells using FOXP3 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-tonsilla, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-tonsilla, antibody was diluted at 1:100
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Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:100
: AO-06-ES4176-50
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