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Antibody Product Overview
| ELK.No | ES4247 |
| Product name | MAG rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | MAG; GMA; Myelin-associated glycoprotein; Siglec-4a |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4099 |
| Human Swiss-Prot | P20916 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MAG |
| Fields | >>Cell adhesion molecules |
| Gene name | MAG |
| Protein name | Myelin-associated glycoprotein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17136 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P20917 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29409 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P07722 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG. AA range:501-550 |
| Specificity | MAG Polyclonal Antibody detects endogenous levels of MAG protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 70kD |
| Background | The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010], |
| Function | function:Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid.,online information:Siglec-4,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to RTN4R., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . Membrane raft . |
| Expression | Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552). |
Additional Images
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Western Blot analysis of HeLa, HepG2 cells using MAG Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES4247-50
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