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Antibody Product Overview
| ELK.No | ES4257 |
| Product name | G-CSFR rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | CSF3R; GCSFR; Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R; CD114 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1441 |
| Human Swiss-Prot | Q99062 |
| Source | Rabbit |
| Isotype | IgG |
| Target | G-CSFR |
| Fields | >>Cytokine-cytokine receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Pathways in cancer |
| Gene name | CSF3R |
| Protein name | Granulocyte colony-stimulating factor receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P40223 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CSF3R. AA range:321-370 |
| Specificity | G-CSFR Polyclonal Antibody detects endogenous levels of G-CSFR protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 92kD |
| Background | The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010], |
| Function | alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in CSF3R may be a cause of severe congenital neutropenia (SCN) in some patients.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 5 fibronectin type-III domains.,subunit:Homodimer. The dimeric receptor binds two CSF3 molecules.,tissue specificity:One or several isofor |
| Subcellular location | [Isoform 2]: Secreted .; Cell membrane ; Single-pass type I membrane protein . |
| Expression | One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. |
Additional Images
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Western Blot analysis of SKOV3 cells using G-CSFR Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES4257-50
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