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Antibody Product Overview
| ELK.No | ES4292 |
| Product name | Dkk-1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | DKK1; Dickkopf-related protein 1; Dickkopf-1; Dkk-1; hDkk-1; SK |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 22943 |
| Human Swiss-Prot | O94907 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Dkk-1 |
| Fields | >>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | DKK1 |
| Protein name | Dickkopf-related protein 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13380 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O54908 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human DKK1. AA range:181-230 |
| Specificity | Dkk-1 Polyclonal Antibody detects endogenous levels of Dkk-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 29kD |
| Background | This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008], |
| Function | function:Inhibitor of Wnt signaling pathway.,similarity:Belongs to the dickkopf family.,tissue specificity:Placenta., |
| Subcellular location | Secreted. |
| Expression | Placenta. |
Additional Images
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Western Blot analysis of Hela cells using Dkk-1 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
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: AO-06-ES4292-50
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