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Antibody Product Overview
| ELK.No | ES4296 |
| Product name | AID rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | AICDA; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 57379 |
| Human Swiss-Prot | Q9GZX7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AID |
| Fields | >>Intestinal immune network for IgA production;>>Primary immunodeficiency |
| Gene name | AICDA |
| Protein name | Activation-induced cytidine deaminase |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11628 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9WVE0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human AICDA. AA range:81-130 |
| Specificity | AID Polyclonal Antibody detects endogenous levels of AID protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 24kD |
| Background | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009], |
| Function | catalytic activity:Cytidine + H(2)O = uridine + NH(3).,cofactor:Zinc.,disease:Defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]. HIGM2 is characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.,function:RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.,online information:AICDA mutation db,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Str |
| Subcellular location | Nucleus . Cytoplasm . Predominantly cytoplasmic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity). . |
| Expression | Strongly expressed in lymph nodes and tonsils. |
Additional Images
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Western Blot analysis of Hela, HepG2 cells using AID Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:100
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: AO-06-ES4296-100
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