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Antibody Product Overview
| ELK.No | ES4317 |
| Product name | CD42d rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | GP5; Platelet glycoprotein V; GPV; Glycoprotein 5; CD42d |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2814 |
| Human Swiss-Prot | P40197 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD42d |
| Fields | >>ECM-receptor interaction;>>Platelet activation;>>Hematopoietic cell lineage |
| Gene name | GP5 |
| Protein name | Platelet glycoprotein V |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | O08742 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25259 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O08770 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380 |
| Specificity | CD42d Polyclonal Antibody detects endogenous levels of CD42d protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 62kD |
| Background | Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010], |
| Function | function:The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.,PTM:The N-terminus is blocked.,similarity:Contains 14 LRR (leucine-rich) repeats.,tissue specificity:Platelets and megakaryocytes., |
| Subcellular location | Membrane; Single-pass type I membrane protein. |
| Expression | Platelets and megakaryocytes. |
Additional Images
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Western Blot analysis of Hela cells using CD42d Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Immunohistochemical analysis of paraffin-embedded human-tonsils, antibody was diluted at 1:100
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: AO-06-ES4317-100
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