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Antibody Product Overview
| ELK.No | ES4359 |
| Product name | CD180 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CD180; LY64; RP105; CD180 antigen; Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD180 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4064 |
| Human Swiss-Prot | Q99467 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CD180 |
| Fields | |
| Gene name | CD180 |
| Protein name | CD180 antigen |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17079 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q62192 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from CD180 antigen at AA range: 221-270 |
| Specificity | CD180 Polyclonal Antibody detects endogenous levels of CD180 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008], |
| Function | disease:Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.,function:May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 17 LRR (leucine-rich) repeats.,subunit:Binds to MD-1.,tissue specificity:Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells., |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. |
| Expression | Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. |
Additional Images
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Western Blot analysis of mouse brain cells using CD180 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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Western Blot analysis of MOUSE-BRAIN cells using CD180 Polyclonal Antibody diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
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: AO-06-ES4359-100
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