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Na+/K+-ATPase α1 (phospho Ser23) rabbit pAb
AO-06-ES4388-50
Antibody Product Overview
| ELK.No | ES4388 |
| Product name | Na+/K+-ATPase α1 (phospho Ser23) rabbit pAb |
| Reactivity | Rat |
| Applications | WB;IF;ELISA |
| Other name | ATP1A1; Sodium/potassium-transporting ATPase subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | |
| Human Swiss-Prot | |
| Source | Rabbit |
| Isotype | IgG |
| Target | Na+/K+-ATPase α1 |
| Fields | |
| Gene name | ATP1A1 |
| Protein name | Sodium/potassium-transporting ATPase subunit alpha-1 |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | 24211 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P06685 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from rat ATP1 alpha1/Na+K+ ATPase1 around the phosphorylation site of Ser23. AA range:15-64 |
| Specificity | Phospho-Na+/K+-ATPase α1 (S23) Polyclonal Antibody detects endogenous levels of Na+/K+-ATPase α1 protein only when phosphorylated at S23. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. IF: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 113kD |
| Background | The ATPase Na+/K+ transporting subunit alpha 1 encoded by ATP1A1 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | |
| Subcellular location | |
| Expression |
Additional Images
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Western Blot analysis of rat cells using Phospho-Na+/K+-ATPase α1 (S23) Polyclonal Antibody
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Immunofluorescence analysis of NIH/3T3 cells, using ATP1 alpha1/Na+K+ ATPase1 (Phospho-Ser23) Antibody. The picture on the right is blocked with the phospho peptide.
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Western blot analysis of lysates from rat brain, using ATP1 alpha1/Na+K+ ATPase1 (Phospho-Ser23) Antibody. The lane on the right is blocked with the phospho peptide.
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: AO-06-ES4388-50
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