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Antibody Product Overview
| ELK.No | ES4422 |
| Product name | OB-cadherin rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | CDH11; Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 1009 |
| Human Swiss-Prot | P55287 |
| Source | Rabbit |
| Isotype | IgG |
| Target | OB-cadherin |
| Fields | |
| Gene name | CDH11 |
| Protein name | Cadherin-11 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12552 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P55288 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDH11. AA range:421-470 |
| Specificity | OB-cadherin Polyclonal Antibody detects endogenous levels of OB-cadherin protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008], |
| Function | function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts., |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. |
| Expression | Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. |
Additional Images
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Western Blot analysis of Jurkat cells using OB-cadherin Polyclonal Antibody
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Western blot analysis of lysates from Jurkat cells, using CDH11 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HeLa cells using Cytochrome P450 1A1/2 antibody.
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: AO-06-ES4422-50
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