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Antibody Product Overview
| ELK.No | ES4445 |
| Product name | CNK1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | CNKSR1; CNK1; Connector enhancer of kinase suppressor of ras 1; Connector enhancer of KSR 1; CNK homolog protein 1; CNK1; hCNK1; Connector enhancer of KSR-like |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10256 |
| Human Swiss-Prot | Q969H4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CNK1 |
| Fields | |
| Gene name | CNKSR1 |
| Protein name | Connector enhancer of kinase suppressor of ras 1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNKR1. AA range:491-540 |
| Specificity | CNK1 Polyclonal Antibody detects endogenous levels of CNK1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 80kD |
| Background | This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], |
| Function | function:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RHO and RALGDS., |
| Subcellular location | Cytoplasm . Membrane ; Peripheral membrane protein . |
| Expression | Brain,Epithelium,Kidney,Liver,Neuroepithelium,Place |
Additional Images
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Western Blot analysis of COLO cells using CNK1 Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Western blot analysis of lysates from COLO205 cells, using CNKR1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from HT-29 cells using CNKSR1 antibody.
: AO-06-ES4445-50
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