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Antibody Product Overview
| ELK.No | ES4497 |
| Product name | TIP60 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | IHC;IF;ELISA |
| Other name | KAT5; HTATIP; TIP60; Histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 10524 |
| Human Swiss-Prot | Q92993 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TIP60 |
| Fields | >>Spinocerebellar ataxia;>>Human T-cell leukemia virus 1 infection |
| Gene name | KAT5 |
| Protein name | Histone acetyltransferase KAT5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 81601 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8CHK4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TIP60. AA range:52-101 |
| Specificity | TIP60 Polyclonal Antibody detects endogenous levels of TIP60 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 59kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008], |
| Function | negative regulation of transcription from RNA polymerase II promoter, regulation of cytokine production, negative regulation of cytokine production, DNA metabolic process, DNA repair, double-strand break repair, chromatin organization, chromatin assembly or disassembly, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid acetylation, response to DNA damage stimulus,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,intracellular signaling cascade, negative regulation of biosynthetic process, positive regulation of biosynthetic process,regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, neg |
| Subcellular location | Nucleus . Chromosome . Cytoplasm . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Nucleus, nucleolus . Cytoplasm, perinuclear region . Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies (PubMed:11262386). Transiently localizes to kinetochores in early mitosis (PubMed:26829474). Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293). Localizes in the cytoplasm and nucleus of round spermatids (By similarity). . |
| Expression | Brain, |
Additional Images
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Immunofluorescence analysis of HeLa cells, using TIP60 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using TIP60 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES4497-100
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