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Antibody Product Overview
| ELK.No | ES4550 |
| Product name | Calpain 9 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | CAPN9; NCL4; Calpain-9; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 10753 |
| Human Swiss-Prot | O14815 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Calpain 9 |
| Fields | |
| Gene name | CAPN9 |
| Protein name | Calpain-9 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9D805 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CAPN9. AA range:481-530 |
| Specificity | Calpain 9 Polyclonal Antibody detects endogenous levels of Calpain 9 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 75kD |
| Background | Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease.,induction:Down-regulated in gastric cancer tissue and in gastric cell lines of differentiated and poorly differentiated types.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 3 EF-hand domains.,tissue specificity:Expressed predominantly in stomach., |
| Subcellular location | intracellular,cytoplasm, |
| Expression | Expressed predominantly in stomach. |
Additional Images
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Western Blot analysis of HuvEc cells using Calpain 9 Polyclonal Antibody
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Western blot analysis of CAPN9 Antibody. The lane on the right is blocked with the CAPN9 peptide.
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: AO-06-ES4550-50
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