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Antibody Product Overview
| ELK.No | ES4628 |
| Product name | Ataxin-2L rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | ATXN2L; A2D; A2LG; A2LP; A2RP; Ataxin-2-like protein; Ataxin-2 domain protein; Ataxin-2-related protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 11273 |
| Human Swiss-Prot | Q8WWM7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Ataxin-2L |
| Fields | >>Amyotrophic lateral sclerosis;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | ATXN2L |
| Protein name | Ataxin-2-like protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q7TQH0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATXN2L. AA range:571-620 |
| Specificity | Ataxin-2L Polyclonal Antibody detects endogenous levels of Ataxin-2L protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 113kD |
| Background | This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | PTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.,sequence caution:Exon duplication.,similarity:Belongs to the ataxin-2 family.,subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation.,tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells., |
| Subcellular location | Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). . |
| Expression | Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells. |
Additional Images
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Western Blot analysis of 293T cells using Ataxin-2L Polyclonal Antibody diluted at 1:2000
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Western blot analysis of lysates from NIH/3T3 and RAW264.7 cells, using ATXN2L Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from 293 cells using ATXN2L antibody.
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: AO-06-ES4628-50
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