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Antibody Product Overview
| ELK.No | ES4652 |
| Product name | MARCH3 rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;IHC;IF;ELISA |
| Other name | MARCH3; RNF173; E3 ubiquitin-protein ligase MARCH3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; MARCH-III; RING finger protein 173 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 115123 |
| Human Swiss-Prot | Q86UD3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MARCH3 |
| Fields | |
| Gene name | MARCH3 |
| Protein name | E3 ubiquitin-protein ligase MARCH3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 320253 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BRX9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 364878 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5XIE5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MARCH3. AA range:111-160 |
| Specificity | MARCH3 Polyclonal Antibody detects endogenous levels of 40605 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 29kD |
| Background | This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013], |
| Function | domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with MARCH2 and STX6., |
| Subcellular location | Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . |
| Expression | Brain,Thalamus, |
Additional Images
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Western Blot analysis of K562 cells using MARCH3 Polyclonal Antibody
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Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MARCH3 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from K562 and COS7 cells, using MARCH3 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from RAW264.7cells using MARCH3 antibody.
: AO-06-ES4652-50
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