Français
English
Antibody Product Overview
| ELK.No | ES4717 |
| Product name | CNG-1 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel; photoreceptor; Rod photoreceptor cG |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1259 |
| Human Swiss-Prot | P29973 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CNG-1 |
| Fields | >>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Phototransduction |
| Gene name | CNGA1 |
| Protein name | cGMP-gated cation channel alpha-1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12788 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P29974 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 85259 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q62927 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNGA1. AA range:401-450 |
| Specificity | CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 80kD |
| Background | The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008], |
| Function | caution:It is uncertain whether Met-1 or Met-5 is the initiator.,disease:Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subuni |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . |
| Expression | Rod cells in the retina. |
Additional Images
No image
Western Blot analysis of HepG2 cells using CNG-1 Polyclonal Antibody
No image
Western blot analysis of CNGA1 Antibody. The lane on the right is blocked with the CNGA1 peptide.
No image
Western blot analysis of the lysates from HepG2 cells using CNGA1 antibody.
No image
: AO-06-ES4717-100
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package