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Antibody Product Overview
| ELK.No | ES4819 |
| Product name | GPR119 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IF;ELISA |
| Other name | GPR119; Glucose-dependent insulinotropic receptor; G-protein coupled receptor 119 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 139760 |
| Human Swiss-Prot | Q8TDV5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GPR119 |
| Fields | >>cAMP signaling pathway;>>Insulin secretion |
| Gene name | GPR119 |
| Protein name | Glucose-dependent insulinotropic receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q7TQP3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPR119. AA range:186-235 |
| Specificity | GPR119 Polyclonal Antibody detects endogenous levels of GPR119 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 37kD |
| Background | This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010], |
| Function | function:Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in the pancreas, especially in the islets., |
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
| Expression | Predominantly expressed in the pancreas, especially in the islets. |
Additional Images
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Western Blot analysis of COLO cells using GPR119 Polyclonal Antibody diluted at 1:1000
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Western blot analysis of SH-SY5Y mouse-kidney lysis using GPR119 antibody. Antibody was diluted at 1:1000
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Immunofluorescence analysis of MCF7 cells, using GPR119 Antibody. The picture on the right is blocked with the synthesized peptide.
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Western blot analysis of lysates from K562 cells, using GPR119 Antibody. The lane on the right is blocked with the synthesized peptide.
: AO-06-ES4819-50
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