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Antibody Product Overview
| ELK.No | ES4873 |
| Product name | AR-α1B rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IF;ELISA |
| Other name | ADRA1B; Alpha-1B adrenergic receptor; Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 147 |
| Human Swiss-Prot | P35368 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AR-α1B |
| Fields | >>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Neuroactive ligand-receptor interaction;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Salivary secretion |
| Gene name | ADRA1B |
| Protein name | Alpha-1B adrenergic receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P97717 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P15823 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADRA1B. AA range:431-480 |
| Specificity | AR-α1B Polyclonal Antibody detects endogenous levels of AR-α1B protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008], |
| Function | function:This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Nucleus membrane; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein . Cytoplasm . Membrane, caveola . Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. |
| Expression | Brain, |
Additional Images
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Western Blot analysis of JK cells using AR-α1B Polyclonal Antibody
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Immunofluorescence analysis of LOVO cells, using ADRA1B Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES4873-100
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