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Antibody Product Overview
| ELK.No | ES4899 |
| Product name | AR α2B rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | IF;ELISA |
| Other name | ADRA2B; ADRA2L1; ADRA2RL1; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2BAR |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 151 |
| Human Swiss-Prot | P18089 |
| Source | Rabbit |
| Isotype | IgG |
| Target | AR α2B |
| Fields | >>cGMP-PKG signaling pathway;>>Neuroactive ligand-receptor interaction |
| Gene name | ADRA2B |
| Protein name | Alpha-2B adrenergic receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P30545 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2B. AA range:161-210 |
| Specificity | AR α2B Polyclonal Antibody detects endogenous levels of AR α2B protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 50kD |
| Observed band (KD) | |
| Background | This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014], |
| Function | function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.,polymorphism:A rare polymorphic framshift in position 451 produces a protein of 542 residues.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. . |
| Expression | Pooled, |
Additional Images
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Immunofluorescence analysis of HepG2 cells, using Adrenergic Receptor alpha-2B Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES4899-100
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