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Antibody Product Overview
| ELK.No | ES5026 |
| Product name | D1DR rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;IHC;IF;ELISA |
| Other name | DRD1; D(1A) dopamine receptor; Dopamine D1 receptor |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 1812 |
| Human Swiss-Prot | P21728 |
| Source | Rabbit |
| Isotype | IgG |
| Target | D1DR |
| Fields | >>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Morphine addiction;>>Alcoholism |
| Gene name | DRD1 |
| Protein name | D(1A) dopamine receptor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13488 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q61616 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24316 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P18901 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DRD1. AA range:135-184 |
| Specificity | D1DR Polyclonal Antibody detects endogenous levels of D1DR protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008], |
| Function | function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.,subunit:Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.,tissue specificity:Detected in caudate, nucleus accumbens and in the olfactory tubercle., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. . |
| Expression | Detected in caudate, nucleus accumbens and in the olfactory tubercle. |
Additional Images
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Western Blot analysis of HepG2 cells using D1DR Polyclonal Antibody
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Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
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Immunofluorescence analysis of MCF7 cells, using DRD1 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DRD1 Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES5026-100
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