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Antibody Product Overview
| ELK.No | ES5123 |
| Product name | 4.1R rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | EPB41; E41P; Protein 4.1; P4.1; 4.1R; Band 4.1; EPB4.1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2035 |
| Human Swiss-Prot | P11171 |
| Source | Rabbit |
| Isotype | IgG |
| Target | 4.1R |
| Fields | |
| Gene name | EPB41 |
| Protein name | Protein 4.1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 269587 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P48193 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EPB41. AA range:626-675 |
| Specificity | 4.1R Polyclonal Antibody detects endogenous levels of 4.1R protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009], |
| Function | disease:Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.,disease:Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.,function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.,PTM:O-glycosylated; contains N-acetylglucosamine side chains in the C-ter |
| Subcellular location | Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Nucleus . |
| Expression | Brain,PCR rescued clones,Reticulocyte,Spleen, |
Additional Images
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Western blot analysis of lysates from HepG2 cells treated with PMA 125ng/ml 30', using EPB41 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5123-100
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