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Antibody Product Overview
| ELK.No | ES5126 |
| Product name | EphA3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | EPHA3; ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2042 |
| Human Swiss-Prot | P29320 |
| Source | Rabbit |
| Isotype | IgG |
| Target | EphA3 |
| Fields | >>Axon guidance |
| Gene name | EPHA3 |
| Protein name | Ephrin type-A receptor 3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P29319 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29210 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O08680 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EPHA3. AA range:831-880 |
| Specificity | EphA3 Polyclonal Antibody detects endogenous levels of EphA3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 120kD |
| Background | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta., |
| Subcellular location | [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted . |
| Expression | Widely expressed. Highest level in placenta. |
Additional Images
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Western Blot analysis of 293T-UV cells using EphA3 Polyclonal Antibody diluted at 1:500
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: AO-06-ES5126-50
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