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Antibody Product Overview
| ELK.No | ES5297 |
| Product name | PDZK3 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | PDZD2; AIPC; KIAA0300; PDZK3; PDZ domain-containing protein 2; Activated in prostate cancer protein; PDZ domain-containing protein 3 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 23037 |
| Human Swiss-Prot | O15018 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PDZK3 |
| Fields | |
| Gene name | PDZD2 |
| Protein name | PDZ domain-containing protein 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | 65034 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9QZR8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PDZD2. AA range:51-100 |
| Specificity | PDZK3 Polyclonal Antibody detects endogenous levels of PDZK3 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 302kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015], |
| Function | disease:May be associated with the early promotion of prostate tumoregenesis.,PTM:A secreted form is produced by caspase-mediated proteolytic cleavage.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 6 PDZ (DHR) domains.,subcellular location:At cell-cell contacts in lung epithelial cells.,subunit:Interacts with SCN10A, CTNND2 and PKP4.,tissue specificity:Expressed (at protein level) in prostate and many prostate tumors., |
| Subcellular location | Nucleus . Cytoplasm . Endoplasmic reticulum . At cell-cell contacts in lung epithelial cells. .; [Processed PDZ domain-containing protein 2]: Secreted . |
| Expression | Isoform 2 is expressed (at protein level) in prostate and many prostate tumors. |
Additional Images
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Immunofluorescence analysis of HepG2 cells, using PDZD2 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human heart tissue, using PDZD2 Antibody. The picture on the right is blocked with the synthesized peptide.
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: AO-06-ES5297-100
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