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Antibody Product Overview
| ELK.No | ES5314 |
| Product name | Raftlin rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;IHC |
| Other name | RFTN1; KIAA0084; MIG2; Raftlin; Cell migration-inducing gene 2 protein; Raft-linking protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 23180 |
| Human Swiss-Prot | Q14699 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Raftlin |
| Fields | |
| Gene name | RFTN1 |
| Protein name | Raftlin |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q6A0D4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RFTN1. AA range:432-481 |
| Specificity | Raftlin Polyclonal Antibody detects endogenous levels of Raftlin protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 65kD |
| Background | function:May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.,similarity:Belongs to the raftlin family.,subcellular location:Associates with lipid rafts.,tissue specificity:Specifically expressed by B-cells (at protein level)., |
| Function | function:May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.,similarity:Belongs to the raftlin family.,subcellular location:Associates with lipid rafts.,tissue specificity:Specifically expressed by B-cells (at protein level)., |
| Subcellular location | Cell membrane ; Lipid-anchor . Cytoplasm . Membrane raft . Endosome . Early endosome . Translocates from cytoplasm to cell membrane where it colocalizes with poly (I:C) and then moves to endosomes where it colocalizes with TLR3 (PubMed:21266579). Translocates from cytoplasm to cell membrane where it colocalizes with TLR4 and then together with TLR4 moves to endosomes, upon lipopolysaccharide stimulation (PubMed:27022195). . |
| Expression | Expressed in B-cells (at protein level) (PubMed:12805216). Expressed in dendritic cells and macrophages (PubMed:27022195, PubMed:21266579). |
Additional Images
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Western Blot analysis of 3T3 cells using Raftlin Polyclonal Antibody
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Western blot analysis of RFTN1 Antibody. The lane on the right is blocked with the RFTN1 peptide.
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Western blot analysis of the lysates from RAW264.7cells using RFTN1 antibody.
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Immunohistochemical analysis of paraffin-embedded human uterus. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
: AO-06-ES5314-50
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