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Ferritin heavy chain rabbit pAb
AO-06-ES5400-50
Antibody Product Overview
| ELK.No | ES5400 |
| Product name | Ferritin heavy chain rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2495 |
| Human Swiss-Prot | P02794 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Ferritin heavy chain |
| Fields | >>Ferroptosis;>>Necroptosis;>>Mineral absorption |
| Gene name | FTH1 |
| Protein name | Ferritin heavy chain |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14319 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P09528 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25319 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P19132 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from the Internal region of human Ferritin heavy chain. |
| Specificity | Ferritin heavy chain Polyclonal Antibody detects endogenous levels of Ferritin heavy chain protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 21kD |
| Background | This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule fo |
| Subcellular location | cell,nucleus,cytoplasm,mitochondrion,cytosol,intracellular ferritin complex,integral component of membrane,autolysosome,extracellular exosome, |
| Expression | Expressed in the liver. |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES5400-50
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