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GAP-43 (phospho Ser41) rabbit pAb
AO-06-ES5456-100
Antibody Product Overview
| ELK.No | ES5456 |
| Product name | GAP-43 (phospho Ser41) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IF;ELISA |
| Other name | GAP43; Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2596 |
| Human Swiss-Prot | P17677 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GAP-43 |
| Fields | |
| Gene name | GAP43 |
| Protein name | Neuromodulin |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14432 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P06837 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29423 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P07936 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GAP43 around the phosphorylation site of Ser41. AA range:8-57 |
| Specificity | Phospho-GAP-43 (S41) Polyclonal Antibody detects endogenous levels of GAP-43 protein only when phosphorylated at S41. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 25kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence., |
| Subcellular location | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. . |
| Expression | Alzheimer cortex,Brain,Subthalamic nucleus, |
Additional Images
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Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GAP43 (Phospho-Ser41) Antibody
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Immunofluorescence analysis of MCF-7 cells, using GAP43 (Phospho-Ser41) Antibody. The picture on the right is blocked with the phospho peptide.
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: AO-06-ES5456-100
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