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Antibody Product Overview
| ELK.No | ES5462 |
| Product name | TIMAP rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;IHC |
| Other name | PPP1R16B; ANKRD4; KIAA0823; Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 26051 |
| Human Swiss-Prot | Q96T49 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TIMAP |
| Fields | |
| Gene name | PPP1R16B |
| Protein name | Protein phosphatase 1 regulatory inhibitor subunit 16B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 228852 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VHQ3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PPP1R16B. AA range:364-413 |
| Specificity | TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 64kD |
| Background | The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015], |
| Function | function:May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.,induction:Inhibited by TGF-beta1.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,tissue specificity:Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis., |
| Subcellular location | Cell membrane . Cell membrane ; Lipid-anchor . Nucleus . Cell projection . Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). . |
| Expression | Brain, |
Additional Images
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Western blot analysis of lysates from mouse brain, using PPP1R16B Antibody. The lane on the right is blocked with the synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human Colon cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES5462-50
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