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Antibody Product Overview
| ELK.No | ES5494 |
| Product name | GCKR rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | GCKR; Glucokinase regulatory protein; Glucokinase regulator |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2646 |
| Human Swiss-Prot | Q14397 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GCKR |
| Fields | |
| Gene name | GCKR |
| Protein name | Glucokinase regulatory protein |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 231103 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91X44 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 25658 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q07071 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Glucokinase Regulator. AA range:211-260 |
| Specificity | GCKR Polyclonal Antibody detects endogenous levels of GCKR protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 68kD |
| Background | This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008], |
| Function | function:Inhibits glucokinase by forming an inactive complex with this enzyme.,similarity:Belongs to the GCKR family.,similarity:Contains 1 SIS domain.,tissue specificity:Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen., |
| Subcellular location | Cytoplasm . Nucleus . Mitochondrion . Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. . |
| Expression | Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. |
Additional Images
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Western blot analysis of lysates from mouse heart and rat heart cells, using Glucokinase Regulator Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5494-100
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