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Cleaved-GGT4 HC (T472) rabbit pAb
AO-06-ES5516-50
Antibody Product Overview
| ELK.No | ES5516 |
| Product name | Cleaved-GGT4 HC (T472) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | GGT7; GGTL3; GGTL5; Gamma-glutamyltransferase 7; GGT 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7; Glutathione hydrolase 7 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2686 |
| Human Swiss-Prot | Q9UJ14 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GGT4 HC |
| Fields | >>Taurine and hypotaurine metabolism;>>Glutathione metabolism;>>Metabolic pathways |
| Gene name | GGT7 |
| Protein name | Gamma-glutamyltransferase 7 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 207182 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q99JP7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 156275 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q99MZ4 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Gamma-glutamyltransferase 4. AA range:423-472 |
| Specificity | Cleaved-GGT4 HC (T472) Polyclonal Antibody detects endogenous levels of fragment of activated GGT4 HC protein resulting from cleavage adjacent to T472. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 50kD |
| Background | This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,function:Cleaves glutathione conjugates.,pathway:Sulfur metabolism; glutathione metabolism.,similarity:Belongs to the gamma-glutamyltransferase family.,subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). Isoform 3 interacts with FAM57A.,tissue specificity:Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea., |
| Subcellular location | Membrane ; Single-pass type II membrane protein . |
| Expression | Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea. |
Additional Images
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Western blot analysis of lysates from Jurkat cells, treated with etoposide 25uM 24h, using Gamma-glutamyltransferase 4 (heavy chain,Cleaved-Thr472) Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5516-50
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