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Antibody Product Overview
| ELK.No | ES5544 |
| Product name | ZIP1 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | SLC39A1; IRT1; ZIP1; ZIRTL; CGI-08; CGI-71; Zinc transporter ZIP1; Solute carrier family 39 member 1; Zinc-iron-regulated transporter-like; Zrt- and Irt-like protein 1; ZIP-1; hZIP1 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 27173 |
| Human Swiss-Prot | Q9NY26 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ZIP1 |
| Fields | >>Alzheimer disease;>>Parkinson disease |
| Gene name | SLC39A1 |
| Protein name | Zinc transporter ZIP1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9QZ03 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC39A1. AA range:111-160 |
| Specificity | ZIP1 Polyclonal Antibody detects endogenous levels of ZIP1 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 38kD |
| Background | This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012], |
| Function | function:Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.,miscellaneous:Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake.,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,subcellular location:Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.,tissue specificity:Ubiquitous. Expressed in most adult and fetal tissues including the epidermis., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. |
| Expression | Ubiquitous. Expressed in most adult and fetal tissues including the epidermis. |
Additional Images
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Western blot analysis of lysates from Jurkat cells, using SLC39A1 Antibody. The lane on the right is blocked with the synthesized peptide.
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Western blot analysis of the lysates from COLO205 cells using SLC39A1 antibody.
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: AO-06-ES5544-100
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