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Antibody Product Overview
| ELK.No | ES5578 |
| Product name | Cadherin-20 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF;ELISA |
| Other name | CDH20; CDH7L3; Cadherin-20 |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 28316 |
| Human Swiss-Prot | Q9HBT6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | Cadherin-20 |
| Fields | |
| Gene name | CDH20 |
| Protein name | Cadherin-20 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 23836 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9Z0M3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 363948 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5DWV1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDH20. AA range:111-160 |
| Specificity | Cadherin-20 Polyclonal Antibody detects endogenous levels of Cadherin-20 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 89kD |
| Observed band (KD) | |
| Background | This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008], |
| Function | function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Expressed in placenta, adult brain, and fetal brain., |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. |
| Expression | Expressed in placenta, adult brain, and fetal brain. |
Additional Images
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Western blot analysis of CDH20 Antibody. The lane on the right is blocked with the CDH20 peptide.
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Immunohistochemistryt analysis of paraffin-embedded human brain, using CDH20 Antibody. The lane on the right is blocked with the CDH20 peptide.
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Immunofluorescence analysis of NIH/3T3 cells, using CDH20 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CDH20 Antibody. The picture on the right is blocked with the synthesized peptide.
: AO-06-ES5578-50
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