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Antibody Product Overview
| ELK.No | ES5628 |
| Product name | GPS2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | GPS2; G protein pathway suppressor 2; GPS-2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2874 |
| Human Swiss-Prot | Q13227 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GPS2 |
| Fields | >>Human T-cell leukemia virus 1 infection |
| Gene name | GPS2 |
| Protein name | G protein pathway suppressor 2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPS2. AA range:11-60 |
| Specificity | GPS2 Polyclonal Antibody detects endogenous levels of GPS2 protein. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 40kD |
| Background | This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008], |
| Function | function:Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.,sequence caution:Wrong choice of frame.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.,tissue specificity:Widely expressed., |
| Subcellular location | Nucleus . Mitochondrion . Cytoplasm, cytosol . Sumoylation regulates the subcellular location (PubMed:24943844). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (By similarity). . |
| Expression | Widely expressed. |
Additional Images
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Western Blot analysis of RAW264.7 cells using GPS2 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of lysates from RAW264.7 cells, using GPS2 Antibody. The lane on the right is blocked with the synthesized peptide.
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: AO-06-ES5628-100
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